The interaction of α-N-(p-toluenesulphonyl)-p-guanidino-L-phenylalanine methyl ester with thrombin and trypsin
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چکیده
منابع مشابه
The Pharmacological Activities of the Metabolites of N-[(Trimethylamineboryl)-Carbonyl]-L-Phenylalanine Methyl Ester
The metabolites of N-[(trimethylamineboryl)-carbonyl]-L-phenylalanine methyl ester 1 proved to be active in a number of pharmacological screens where the parent had previously demonstrated potent activity. The proposed metabolites demonstrated significant activity as cytotoxic, hypolipidemic, and anti-inflammatory agents. In cytotoxicity screens several of the proposed metabolites afforded bett...
متن کاملThe Behaviour of Trypsin towards a-N-Methyl-aE-N-toluene-p-sulphonyl-L-lysine p-Naphthyl Ester A NEW METHOD FOR DETERMINING THE ABSOLUTE MOLARITY OF SOLUTIONS OF TRYPSIN By D. T. ELMORE
1. ac-N-Methyl-oc-N-toluene-p-sulphonyl-L-lysine ,B-naphthyl ester (MTLNE) was synthesized as its hydrobromide and shown to be slowly hydrolysed by bovine pancreatic trypsin. The acylation step, however, is so much faster than deacylation of the acyl-enzyme that spectrophotometric measurement of the 'burst' of ,B-naphthol provides a convenient method for determining the absolute molarity of try...
متن کاملexistence and approximate $l^{p}$ and continuous solution of nonlinear integral equations of the hammerstein and volterra types
بسیاری از پدیده ها در جهان ما اساساً غیرخطی هستند، و توسط معادلات غیرخطی بیان شده اند. از آنجا که ظهور کامپیوترهای رقمی با عملکرد بالا، حل مسایل خطی را آسان تر می کند. با این حال، به طور کلی به دست آوردن جوابهای دقیق از مسایل غیرخطی دشوار است. روش عددی، به طور کلی محاسبه پیچیده مسایل غیرخطی را اداره می کند. با این حال، دادن نقاط به یک منحنی و به دست آوردن منحنی کامل که اغلب پرهزینه و ...
15 صفحه اولThe trypsin-catalyzed hydrolysis of N alpha-benzyloxycarbonyl-L-lysine p-nitrophenyl ester in dimethylsulfoxide at sub-zero temperatures.
The effect of sub-zero temperatures and aqueous dimethylsulfoxide solutions on the trypsin-catalyzed hydrolysis of N=-benzyloxycarbonyl-L-lysine p-nitrophenyl ester has been investigated. With increasing dimethylsulfoxide concentration at O’, keat decreases in proportion to the decreased water concentration; however, K,,, increases by 2 orders of magnitude. The effect on K,,, can be accounted f...
متن کاملN-Cinnamoyl-l-phenylalanine methyl ester
As part of an ongoing investigation into the development of N-substituted amino acids as building blocks for dynamic combinatorial chemistry, we report the structure of the title compound, C(19)H(19)NO(3). This compound crystallizes as discrete mol-ecules. The cinnamoyl group is non-planar, with the phenyl ring and the amide twisted out of the ethyl-ene plane. The benzyl and ester groups lie ab...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1978
ISSN: 0264-6021
DOI: 10.1042/bj1690157